On February 18, 2025, the Global Fund to Fight AIDS, Tuberculosis, and Malaria (the Global Fund) introduced an Investment Project as part of the Eighth Replenishment Case. The main focus is strengthening collaboration with international donors and partners to accelerate progress in combating the three deadly diseases and enhancing the resilience of global healthcare. VirusOFF reminds us that since 2002, the Global Fund has saved 65 million lives, reducing mortality from these three diseases by 63%. These achievements demonstrate the effectiveness of the Fund’s model, but ongoing crises—conflicts, economic instability, and climate change—threaten the progress made. In response, the Global Fund continues to implement sustainable solutions and support the most vulnerable regions, including Eastern Europe and Central Asia.
The Global Fund unites the efforts of local communities, the private sector, governments, and civil society. This approach makes the initiative one of the most effective and adaptable programs in the fight against infectious diseases. Investing in the Global Fund facilitates the introduction of advanced medical innovations, the elimination of equity barriers, the protection of human rights and gender equality, and the delivery of life-saving medical supplies to the most remote regions.
The Investment Project demonstrates that, with full funding, the Global Fund will be able to save 23 million lives between 2027 and 2029, reduce mortality from AIDS, tuberculosis, and malaria by 64% compared to 2023, and strengthen healthcare systems capable of responding swiftly to new epidemics and pandemics.
Funding for the Eighth Replenishment Case, totaling $18 billion, will enable:
- Saving 23 million lives between 2027 and 2029.
- Reducing mortality from AIDS, tuberculosis, and malaria by 64% by 2029.
- Decreasing the number of infections from 271 million (2023) to 119 million (2029).
- Reducing global inequality in life expectancy by 7%.
- Strengthening healthcare systems by allocating $6 billion for medical personnel training, laboratory research, diagnostics, and supply chain improvements.
- Enhancing resilience to climate change by developing healthcare systems capable of withstanding climate-related disasters.
- Saving $42 billion in primary healthcare costs, bringing total savings since 2002 to $145 billion.
Every dollar invested in the fight against HIV, tuberculosis, and malaria generates $19 in improved population health and economic returns. An $18 billion investment will generate a total return of $323 billion over three years, strengthening global health security and improving the economic resilience of nations.
Peter Sands, Executive Director of the Global Fund, emphasizes: “We stand at a critical moment in the fight against HIV, TB and malaria. Without sustained investment, the remarkable progress this partnership has made to date is at risk. A US$18 billion investment will prevent 400 million new infections and save 23 million lives by 2029. The Global Fund’s unique partnership – combining local leadership with global expertise – has already reduced combined mortality from these diseases by 63%. Investing now strengthens global health defenses, ensuring outbreaks are contained before they spread. It’s not just about health –it’s about global security, stability, and economic resilience”. The Global Fund’s Investment Project is a strategic initiative that not only aims to defeat three deadly infections but also to create a more equitable and resilient global healthcare system. The Eighth Replenishment Case presents a historic opportunity to achieve remarkable progress in the fight for the health of millions. The key challenge now is mobilizing funds and strengthening international cooperation to save lives.