The Global Fund to Fight AIDS, Tuberculosis and Malaria has released its annual Results Report, confirming an impressive milestone – 70 million lives saved since 2002. At the same time, the organization warns that without renewed commitments and financing, decades of progress could be undone. The Fund’s Eighth Replenishment, launched in 2025, will be decisive in keeping the world on track to eliminate the three deadly diseases.
Global impact over two decades
In less than a quarter of a century, the Global Fund partnership – bringing together governments, local communities and health workers – has reduced the mortality rate from AIDS, tuberculosis and malaria by 63%, and cut new cases by 42%.
Executive Director Peter Sands stressed that success is possible thanks to “the right tools, strong partnerships and sustained investments.” He emphasized that in today’s geopolitical context there is no room for complacency, and the organization itself is ready for bold change: to maximize every dollar, respond quickly to countries’ evolving needs, and strengthen national health systems.
Achievements in the fight against AIDS
In 2024, in Global Fund–supported countries, 88% of people living with HIV knew their status, 79% were receiving therapy, and 74% achieved viral suppression – record levels. The use of pre-exposure prophylaxis (PrEP) increased by 325% in a single year, reaching 1.4 million people. By the end of 2024, the Fund also announced plans to provide access to the innovative injectable lenacapavir to 2 million people.
Since its creation, AIDS-related deaths in partner countries have decreased by 82%, and new infections by 73%. However, the threat remains: in 2024, 630,000 people died from AIDS-related causes, and there were 1.3 million new infections – 3.5 times higher than the global target set for 2025.
Tuberculosis: the deadliest infection
In 2023, tuberculosis treatment coverage in Global Fund–supported countries reached 75%, the highest in history. Among patients with drug-resistant TB, 44% started treatment, with an overall treatment success rate of 88%. In addition, 91% of HIV-positive TB patients were on antiretroviral therapy.
The rollout of new technologies – such as AI-powered diagnostics and portable digital X-rays – significantly improved detection and treatment. Since 2002, TB mortality has dropped by 57%, and incidence by 28%. Still, tuberculosis remains the world’s deadliest infectious disease, claiming around 1.3 million lives in 2023.
Malaria: progress and new challenges
In 2023, 61% of people had access to insecticide-treated mosquito nets, and more than half of those at risk were using them. Over 95% of people with malaria symptoms were tested. Since 2002, through prevention, treatment and resistance control, malaria mortality has been reduced by 51%, and incidence by 26%.
The world has seen examples of success: Suriname and Timor-Leste were certified malaria-free by WHO in 2025. However, conflicts, climate change and rising drug resistance threaten to bring the disease back, posing particular risks for children and pregnant women.
Investments in health systems
In 2024, the Fund invested US$2.7 billion in over 100 countries to strengthen health systems and disease surveillance. These resources helped detect and control new outbreaks and improved the fight against co-infections such as hepatitis B and C and HPV, while boosting preparedness for threats like Ebola and Marburg.
The Fund also supports the development of national planning, logistics, workforce and digital solutions, enabling countries to move toward self-reliance. Already, 52 programs in 38 countries have transitioned out of Fund support, and by 2026, another 12 programs are expected to do so.
Responding to conflicts and crises
Armed conflicts and humanitarian crises continue to threaten health progress. Fragile contexts – home to 16% of the global population – account for two-thirds of malaria cases, one-quarter of TB cases, and 17% of new HIV infections.
The Fund ensures uninterrupted treatment in countries such as Ukraine, Sudan and Syria, and actively uses its Emergency Fund for rapid responses – including in Mozambique, Afghanistan and Haiti.
Eighth Replenishment: a chance for the future
In 2025, the Global Fund launched its Eighth Replenishment, co-hosted by South Africa and the United Kingdom. The key goal is to safeguard progress and prevent epidemic resurgence.
Several countries – Australia, Luxembourg, Norway and Spain – have already pledged contributions, along with private donors including CIFF and Takeda. If successful, the campaign could save an additional 23 million lives between 2027 and 2029, and cut mortality from the three diseases by 64% by 2029.
Read the full Global Fund Results Report: